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Courses
Courses
Choosing a course is one of the most important decisions you'll ever make! View our courses and see what our students and lecturers have to say about the courses you are interested in at the links below.
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University Life
University Life
Each year more than 4,000 choose NUI Galway as their University of choice. Find out what life at NUI Galway is all about here.
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About NUI Galway
About NUI Galway
Since 1845, NUI Galway has been sharing the highest quality teaching and research with Ireland and the world. Find out what makes our University so special – from our distinguished history to the latest news and campus developments.
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Colleges & Schools
Colleges & Schools
NUI Galway has earned international recognition as a research-led university with a commitment to top quality teaching across a range of key areas of expertise.
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Research
Research
NUI Galway’s vibrant research community take on some of the most pressing challenges of our times.
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Business & Industry
Guiding Breakthrough Research at NUI Galway
We explore and facilitate commercial opportunities for the research community at NUI Galway, as well as facilitating industry partnership.
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Alumni, Friends & Supporters
Alumni, Friends & Supporters
There are over 90,000 NUI Galway graduates Worldwide, connect with us and tap into the online community.
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Community Engagement
Community Engagement
At NUI Galway, we believe that the best learning takes place when you apply what you learn in a real world context. That's why many of our courses include work placements or community projects.
Staff Profiles
Brian McStay
Personal Professor In Biochemistry BA, PhD
Contact Details
Personal Professor In Biochemistry
Biochemistry
School of Natural Sciences
Nui Galway
T: Ext. 2423
E: brian.mcstay@nuigalway.ie
Biochemistry
School of Natural Sciences
Nui Galway
T: Ext. 2423
E: brian.mcstay@nuigalway.ie

Biography
Peer Reviewed Journals
Year | Publication | |
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(2014) | 'Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division'
Grob, A,Colleran, C,McStay, B (2014) 'Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division'. Genes & Development, 28 :220-230 [DOI] [Details] |
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(2014) | 'Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division'
Alice Grob, Brian McStay (2014) 'Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division'. Cell Cycle, 13 (16):2501-2508 [Details] |
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(2014) | 'Ribosome biogenesis: Achilles heel of cancer?'
van Sluis M, McStay B (2014) 'Ribosome biogenesis: Achilles heel of cancer?'. Gene, 5 (5-6):152-153 [Details] |
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(2013) | 'The shared genomic architecture of human nucleolar organizer regions'
Floutsakou, I,Agrawal, S,Nguyen, TT,Seoighe, C,Ganley, ARD,McStay, B (2013) 'The shared genomic architecture of human nucleolar organizer regions'. Genome Research, 23 :2003-2012 [DOI] [Details] |
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(2013) | 'Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human'
Albert B, Colleran C, Léger-Silvestre I, Berger AB, Dez C, Normand C, Perez-Fernandez J, McStay B, Gadal O (2013) 'Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human'. Nucleic Acids Research, 41 (22):10135-10149 [DOI] [Details] |
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(2012) | 'NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing'
Freed, EF,Prieto, JL,McCann, KL,McStay, B,Baserga, SJ (2012) 'NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing'. Plos Genetics, 8 [DOI] [Details] |
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(2011) | 'Replication timing of pseudo-NORs'
Smirnov, E,Cmarko, D,Kovacik, L,Hagen, GM,Popov, A,Raska, O,Prieto, JL,Ryabchenko, B,Arnim, F,McStay, B,Raska, I (2011) 'Replication timing of pseudo-NORs'. Journal Of Structural Biology, 173 :213-218 [DOI] [Details] |
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(2011) | 'UBF an essential player in maintenance of active NORs and nucleolar formation'
Grob, A., Colleran, C., McStay, B. (2011) 'UBF an essential player in maintenance of active NORs and nucleolar formation'. Protein Reviews, 15 :83-103 [Details] |
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(2009) | 'A novel SSU processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5 and DBP4'
Turner AJ, Knox AA, Prieto JL, McStay B, Watkins NJ (2009) 'A novel SSU processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5 and DBP4'. Mol Cell Biol, 29 (11):3007-3017 [Details] |
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(2008) | 'The epigenetic regulation of ribosomal gene expression'
McStay B, Grummt I (2008) 'The epigenetic regulation of ribosomal gene expression'. Annu Rev Cell Dev Biol, 24 :131-157 [Details] |
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(2008) | 'Pseudo-NORs: a novel model for studying nucleoli'
Prieto JL, McStay B. (2008) 'Pseudo-NORs: a novel model for studying nucleoli'. BBA Molecular Cell Research, 1783 :2116-2123 [Details] |
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(2008) | 'Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis'
Grob A., Roussel P., Wright J.E., McStay B., Hernandez-Verdun D. and Sirri V. (2008) 'Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis'. J.Cell Sci, [Details] |
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(2007) | 'Factors linking transcription and processing of pre-rRNA in human cells are recruited to nucleolar organiser region chromatin independent of transcription'
Prieto, J.L. and McStay B (2007) 'Factors linking transcription and processing of pre-rRNA in human cells are recruited to nucleolar organiser region chromatin independent of transcription'. Genes and Development, 21 :2041-2054 [Details] |
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(2006) | 'Nucleolar dominance: a model for rRNA gene silencing'
McStay, B. (2006) 'Nucleolar dominance: a model for rRNA gene silencing'. Genes and Development, 20 :1207-1214 [Details] |
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(2006) | 'A role for UBF in organising ribosomal gene chromatin'
Wright, J.E., Mais, C., Prieto, J.L. and McStay B (2006) 'A role for UBF in organising ribosomal gene chromatin'. Biochem Soc Symp, 73 :77-84 [Details] |
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(2006) | 'Nucleolar protein Upstream Binding Factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis'
F. J. Lawrence, B. McStay and D. A. Matthews (2006) 'Nucleolar protein Upstream Binding Factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis'. J. Cell. Sci, 119 :2621-2631 [Details] |
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(2005) | 'UBF Binding Site Arrays Form Pseudo-NORs and Sequester the RNA Pol I Transcription Machinery'
Mais, C., Wright, J.E., Prieto, J.L., Raggett, S.L. and McStay B. (2005) 'UBF Binding Site Arrays Form Pseudo-NORs and Sequester the RNA Pol I Transcription Machinery'. Genes and Development, 19 :50-64 [Details] |
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(2005) | 'Nucleolar biogenesis; the first small steps'
Prieto, J.L. and McStay B (2005) 'Nucleolar biogenesis; the first small steps'. Biochemical Society Transactions, 33 (6):1441-1443 [Details] |
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(2002) | 'UBF binding in vivo is not restricted to regulatory sequences within the vertebrate rDNA repeat'
Audrey C. O'Sullivan, Gareth J. Sullivan and Brian McStay (2002) 'UBF binding in vivo is not restricted to regulatory sequences within the vertebrate rDNA repeat'. Mol.Cell.Bio, 22 :657-668 [Details] |
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(2002) | 'On the formation of amplified nucleoli during early Xenopus oogenesis'
Mais C, McStay B, Scheer U. (2002) 'On the formation of amplified nucleoli during early Xenopus oogenesis'. J Struct Biol, 140 :214-226 [Details] |
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(2002) | 'Oddpols united: new insights into transcription by RNA polymerases I and III'
McStay B, Paule M, Schultz MC, Willis I, Pikaard CS (2002) 'Oddpols united: new insights into transcription by RNA polymerases I and III'. Gene Expr, 10 :263-269 [Details] |
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(2001) | 'Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions can associate with heterologous nucleoli'
Sullivan, G.J. Bridger, J.M., Cuthbert, A.P., Newbold, R.. Bickmore, W.A. and McStay. (2001) 'Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions can associate with heterologous nucleoli'. EMBO Journal, 20 :2867-2877 [Details] |
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(1997) | 'Association of the nucleolar transcription factor UBF with the transcriptionally inactive rRNA genes of pronuclei and early Xenopus embryos'
Bell, P., Mais, C., McStay, B. and Scheer, U. (1997) 'Association of the nucleolar transcription factor UBF with the transcriptionally inactive rRNA genes of pronuclei and early Xenopus embryos'. J.Cell Science, 110 :2053-2063 [Details] |
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(1997) | 'The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter'
McStay, B., Sullivan, G.J. and Cairns C. (1997) 'The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter'. EMBO Journal, 16 :396-405 [Details] |
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(1996) | 'Upstream Binding Factor stabilizes Rib1, the TATA-binding-protein-containing RNA Polymerase I transcription factor, by multiple protein interactions in a DNA-independent manner'
Bodeker, M., Cairns,C and McStay,B. (1996) 'Upstream Binding Factor stabilizes Rib1, the TATA-binding-protein-containing RNA Polymerase I transcription factor, by multiple protein interactions in a DNA-independent manner'. Mol. Cell. Biol, 16 :5572-5578 [Details] |
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(1995) | 'HMG box 4 is the principal determinant of species psecificity in the RNA polymerase I transcription factor UBF'
Cairns, C. and McStay, B. (1995) 'HMG box 4 is the principal determinant of species psecificity in the RNA polymerase I transcription factor UBF'. Nuc. Acids Res, 22 :4583-4590 [Details] |
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(1995) | 'UBF an architectural element for RNA polymerase I promoters'
Reeder, R.H., Pikaard, C.S. and McStay, B. (1995) 'UBF an architectural element for RNA polymerase I promoters'. Nucleic Acids and Molecular Biology, 9 :251-263 [Details] |
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(1995) | 'Identification and cDNA cloning of a xenopus nucleolar phosphoprotein xNopp180, that is the homolog of the rat nucleolar protein Nopp140'
Cairns, C. and McStay, B. (1995) 'Identification and cDNA cloning of a xenopus nucleolar phosphoprotein xNopp180, that is the homolog of the rat nucleolar protein Nopp140'. J. Cell Science, 108 :3339-3347 [Details] |
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(1994) | 'xUBF, an RNA polymerase I transcription factor, crosslinks DNA'
Hu,C.H., McStay B.M. and Reeder, R.H. (1994) 'xUBF, an RNA polymerase I transcription factor, crosslinks DNA'. Mol. Cell. Biol, 14 :2871-2882 [Details] |
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(1993) | 'Efficient expression of a protein coding gene under the control of an RNA polymerase I promoter'
Palmer, T., Miller, A.D., Reeder, R.H. and McStay, B.M. (1993) 'Efficient expression of a protein coding gene under the control of an RNA polymerase I promoter'. Nucleic Acids Res, 21 :3451-3457 [Details] |
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(1991) | 'xUBF and Rib I are both required for formation of a stable RNA polymerase I promoterv complex in X.laevis'
McStay, B., Hu C. H., Pikaard, C.S. and Reeder, R.H. (1991) 'xUBF and Rib I are both required for formation of a stable RNA polymerase I promoterv complex in X.laevis'. EMBO journal, 10 :2297-2303 [Details] |
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(1991) | 'xUBF contains a novel dimerization domain essential for RNA polymerase I transcription'
McStay, B., Frazier, M. W. and Reeder, R.H. (1991) 'xUBF contains a novel dimerization domain essential for RNA polymerase I transcription'. Genes and Development, 5 :1957-1968 [Details] |
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(1990) | 'An RNA polymerase I termination site can stimulate the adjacent ribosomal gene promoter by two distinct mechanisms in Xenopus laevis'
McStay, B. and Reeder, R.H. (1990) 'An RNA polymerase I termination site can stimulate the adjacent ribosomal gene promoter by two distinct mechanisms in Xenopus laevis'. Genes and Devolpment, 4 :1240-1252 [Details] |
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(1990) | 'A DNA-binding protein is required for termination of transcription in Xenopus laevis'
McStay, B. and Reeder, R.H. (1990) 'A DNA-binding protein is required for termination of transcription in Xenopus laevis'. Mol.Cell.Biol, 10 :2793-2800 [Details] |
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(1989) | 'The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor'
Pikaard, C.S., McStay, B.M., Schultz, M.C., Bell, S.P. and Reeder, R.H. (1989) 'The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor'. Genes and Development, 3 :1779-1788 [Details] |
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(1987) | 'Processing and termination of RNA polymerase I transcripts'
Reeder, R.H., Labhart, P.L. and Mc Stay, B. (1987) 'Processing and termination of RNA polymerase I transcripts'. BioEssays, 6 :108-112 [Details] |
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(1987) | 'Linker scanner mutagenesis of the Xenopus laevis ribosomal gene promoter'
Reeder, R.H., Pennock, D., McStay, B., Roan, J., Tolentino, E. and Walker, P. (1987) 'Linker scanner mutagenesis of the Xenopus laevis ribosomal gene promoter'. Nucl. Acids Res, 15 :7429-7441 [Details] |
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(1986) | 'A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter'
McStay, B. and Reeder, R.H. (1986) 'A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter'. Cell, 47 :913-920 [Details] |
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(1983) | 'The origin of the rRNA precursor from X.borealis analysed in vivo and in vitro'
McStay, B. and Bird, A.P. (1983) 'The origin of the rRNA precursor from X.borealis analysed in vivo and in vitro'. Nucl. Acids Res, 11 :8167-8181 [Details] |
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(1983) | 'DNaseI Hypersensitive sites at promoter like sequences in the spacer of X.laevis and X. Borealis'
LaVolpe, A., Taggart, M.,McStay, B., and Bird, A.P. (1983) 'DNaseI Hypersensitive sites at promoter like sequences in the spacer of X.laevis and X. Borealis'. Nucl. Acids Res, 11 :5361-5380 [Details] |
Abstract
Year | Publication | |
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(2011) | DISCOVERY OF A NORTH AMERICAN INDIAN CHILDHOOD CIRRHOSIS-ASSOCIATED PROTEIN THAT IS REQUIRED FOR PRE-RRNA TRANSCRIPTION AND PROCESSING.
Freed, EF,Prieto, JL,McStay, B,Baserga, SJ (2011) DISCOVERY OF A NORTH AMERICAN INDIAN CHILDHOOD CIRRHOSIS-ASSOCIATED PROTEIN THAT IS REQUIRED FOR PRE-RRNA TRANSCRIPTION AND PROCESSING. Abstract [Details] |
Meeting
Year | Publication | |
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(2013) | NOL11, implicated in the pathogenesis of North American Indian Childhood Cirrhosis, is required for pre-rRNA transcription and processing.
Baserga, S,Freed, E,Prieto, JL,McCann, K,McStay, B (2013) NOL11, implicated in the pathogenesis of North American Indian Childhood Cirrhosis, is required for pre-rRNA transcription and processing. Meeting [Details] |